A 76-year-old woman with mild neurocognitive disorder, overactive bladder, and generalized anxiety disorder is referred to the PMHNP after a recent hospitalization for delirium. Her current medications include oxybutynin 5 mg TID, paroxetine 20 mg daily, and diphenhydramine 25 mg at bedtime. The PMHNP calculates her cumulative anticholinergic burden. Which of the following best describes the clinical significance of anticholinergic burden in this patient?