A 35-year-old man with a confirmed diagnosis of bipolar I disorder presents during a depressive episode with a PHQ-9 score of 17. He has a history of two prior manic episodes, the most recent requiring hospitalization eight months ago. He is currently maintained on a mood stabilizer with adequate serum levels. He reports no current manic or hypomanic symptoms and denies psychotic features. He asks his PMHNP about adding a medication specifically for his depressive symptoms. Which of the following best reflects the key consideration in selecting a treatment for this patient's bipolar depression?