hardvortioxetinemultimodalcognitive symptoms5-HT receptor subtypesprocognitivemajor depressive disorder
A 40-year-old female with major depressive disorder and prominent cognitive complaints including poor concentration, mental fog, and difficulty with word-finding has had partial response to sertraline 200 mg daily with adequate improvement in mood but persistent cognitive symptoms. She also reports significant SSRI-related sexual dysfunction. The PMHNP considers switching to vortioxetine. Which of the following best describes vortioxetine's multimodal mechanism and its relevance to this patient's cognitive symptoms?