beginnertrazodoneSARIinsomniaH1 antagonism5-HT2A antagonismdose-dependent pharmacology
A 45-year-old male with major depressive disorder currently treated with fluoxetine 40 mg daily reports persistent insomnia despite adequate antidepressant response. The PMHNP prescribes trazodone 50 mg at bedtime. The patient asks how this medication works differently from his fluoxetine. Which of the following best describes trazodone's pharmacological profile at the low dose prescribed for insomnia?