A PMHNP is comparing two antidepressants for a 48-year-old woman with moderate major depressive disorder. Medication A has a number needed to treat (NNT) of 4 for achieving clinical response and a number needed to harm (NNH) of 12 for significant weight gain. Medication B has an NNT of 8 for clinical response and an NNH of 50 for significant weight gain. The patient has a BMI of 32, pre-diabetes, and expresses strong concern about weight gain. Which of the following best applies these metrics to clinical decision-making?