A 48-year-old male with alcohol use disorder, severe, presents after completing a medically supervised detoxification. He reports a strong craving to drink and a pattern of escalating consumption once he starts drinking. He has no history of opioid use and his liver function tests show mildly elevated AST and ALT. The PMHNP is deciding between naltrexone and acamprosate. Which of the following best guides the medication selection for this patient?