intermediateMAOItyraminehypertensive crisistranylcypromine
A 60-year-old male with treatment-resistant depression has been started on tranylcypromine 30 mg daily after failing multiple other antidepressant classes. During a follow-up visit, he reports consuming a meal of aged cheddar cheese, cured salami, and red wine the previous evening and now has a severe occipital headache, diaphoresis, and a blood pressure of 210/120 mmHg. Which of the following best explains the pathophysiology of this reaction?