hardevidence-based practiceresearch interpretationstatistical significanceclinical significanceRCTdepression
A PMHNP is reviewing a recently published randomized controlled trial evaluating a new adjunctive medication for treatment-resistant depression. The study reports that the treatment group showed statistically significant improvement compared to placebo (p = 0.03) with a mean reduction in HAM-D scores of 2.1 points (95% CI: 0.2–4.0) over 8 weeks. The study enrolled 500 participants. The PMHNP is considering whether to incorporate this medication into practice. Which of the following represents the most accurate interpretation of these findings?