hardhepatic impairmentcirrhosisantidepressantduloxetinedose adjustment
A 55-year-old man with alcohol use disorder in early remission and compensated cirrhosis (Child-Pugh Class B) is referred for treatment of major depressive disorder. His PHQ-9 is 18. His hepatologist confirms stable liver function with albumin 3.0, INR 1.5, and mild ascites. He is not taking any hepatotoxic medications. The PMHNP needs to select an antidepressant. Which of the following is the most appropriate approach?