advancedendocannabinoid systemCB1 receptorcannabispsychosis riskneurodevelopment
A 26-year-old male with a history of daily cannabis use since age 15 presents with a first episode of psychosis including paranoid delusions and disorganized thinking. After stabilization on risperidone, the PMHNP provides psychoeducation about the endocannabinoid system and cannabis-related psychiatric risk. His family asks why cannabis affected his brain this way when others seem to use it without such consequences.