intermediatecircadian rhythmsuprachiasmatic nucleusbipolar disordermelatoninclock genesshift worksocial zeitgeber
A 38-year-old man with bipolar I disorder presents with a manic episode that began 5 days after starting a new overnight shift job. He has a history of mood episodes triggered by sleep schedule disruptions. The PMHNP considers the neurobiological relationship between circadian rhythm disruption and mood destabilization in bipolar disorder. Which of the following best describes the circadian-mood connection?