intermediatebuspironeCYP3A4drug interactionitraconazolepharmacokinetics
A 44-year-old male with generalized anxiety disorder has been well-controlled on buspirone 15 mg twice daily for 8 months. He presents with a new diagnosis of onychomycosis, and his dermatologist plans to start itraconazole 200 mg daily for 12 weeks. The patient's other medications include lisinopril 10 mg daily. The PMHNP is consulted about the safety of continuing buspirone during antifungal treatment. Which of the following is the most appropriate recommendation?