intermediatetreatment-resistant depressionketamineadequate trialaugmentationbipolar screening
A 40-year-old female presents with persistent sadness, hopelessness, and passive suicidal ideation ("I wouldn't mind not waking up"). She has a 15-year history of depression with multiple SSRI trials. She asks about ketamine treatment. Before considering ketamine, what should the PMHNP assess?