A 52-year-old woman presents with a six-month history of depressed mood, anhedonia, insomnia, fatigue, and difficulty concentrating, meeting criteria for major depressive disorder with a PHQ-9 score of 18. Her medical history is significant for compensated hepatic cirrhosis secondary to non-alcoholic steatohepatitis, currently managed by her gastroenterologist. Her laboratory results show a Child-Pugh score of B, mildly elevated transaminases, and an albumin of 3.0 g/dL. She has no history of substance use, no current suicidal ideation, and is taking no psychotropic medications. The PMHNP is formulating an antidepressant treatment plan. Which of the following best describes the most appropriate pharmacological consideration for this patient?