EPS Management · Anticholinergics & Beta-Blockers

Diphenhydramine

Brand: Benadryl (OTC), ZzzQuil, Unisom SleepGels, Tylenol PM (combination), Advil PM (combination)

First-generation antihistamine (H1 antagonist) with significant anticholinergic properties

6 cards

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Card Topics

core (1)trap (2)risk (2)population (1)

All Cards

1.What is diphenhydramine's key psychiatric role?

2.Why is diphenhydramine NOT a good chronic sleep aid?

3.What is the 'hidden OTC burden' problem with diphenhydramine?

4.An elderly patient on clozapine takes nightly Benadryl. Her family reports worsening memory. Dementia workup?

5.Why is diphenhydramine on the Beers list?

6.What is the abuse risk of diphenhydramine?

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