Antidepressants · SSRIs

Paroxetine

Brand: Paxil (IR), Paxil CR (controlled-release), Brisdelle (low-dose for vasomotor symptoms), Pexeva

Selective serotonin reuptake inhibitor (SSRI)

7 cards

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Card Topics

risk (1)trap (2)population (2)interaction (1)dosing (1)

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1.Why does paroxetine have the worst discontinuation syndrome among SSRIs?

2.Which SSRI is listed on the Beers Criteria as potentially inappropriate for older adults, and why?

3.Why is paroxetine the SSRI most clinicians avoid in pregnancy?

4.Paroxetine CYP profile and key difference from fluoxetine's CYP inhibition.

5.Patient stops paroxetine 40mg cold turkey. Three days later: brain zaps, dizziness, nausea, flu-like symptoms. What is happening? (Not serotonin syndrome.)

6.Name two clinical niches where paroxetine is specifically preferred over other SSRIs.

7.Paroxetine has nonlinear pharmacokinetics at higher doses. Why?

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