A 56-year-old female with major depressive disorder (PHQ-9 score of 18) and comorbid diabetic peripheral neuropathy causing burning and shooting pain in both feet (7/10 severity) presents for treatment. Gabapentin provided inadequate pain relief, and she is currently on no antidepressant. The PMHNP selects duloxetine 60 mg daily. Which of the following best supports this medication choice?