Questions/Psychopharmacology/Q45 of 70
intermediatearipiprazolepartial agonismakathisiadopamine D2 receptornigrostriatal pathway
A 32-year-old female with schizophrenia is switched from risperidone to aripiprazole 15 mg daily due to hyperprolactinemia and 20-pound weight gain. Two weeks after reaching the target dose, she reports an internal sense of restlessness and inability to sit still, and she paces continuously during the appointment. Which of the following best explains why aripiprazole is particularly associated with this side effect?
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